Sulindac Sulfide Reverses Aberrant Self-Renewal of Progenitor Cells Induced by the AML-Associated Fusion Proteins PML/RARα and PLZF/RARα

Chromosomal translocations can lead to the formation of chimeric genes encoding fusion proteins such as PML/RARα, PLZF/RARα, and AML-1/ETO, which are able to induce and maintain acute myeloid leukemia (AML). One key mechanism in leukemogenesis is increased self renewal of leukemic stem cells via abe...

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Main Authors: Steinert, Gunnar, Oancea, Claudia, Roos, Jessica, Hagemeyer, Heike, Maier, Thorsten, Ruthardt, Martin, Puccetti, Elena
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139642/
https://ncbi.nlm.nih.gov/pubmed/21811629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022540
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