Aberrant Corepressor Interactions Implicated in PML-RARα and PLZF-RARα Leukemogenesis Reflect an Altered Recruitment and Release of Specific NCoR and SMRT Splice Variants

Human acute promyelocytic leukemia is causally linked to chromosomal translocations that generate chimeric retinoic acid receptor-α proteins (x-RARα fusions). Wild-type RARα is a transcription factor that binds to the SMRT/NCoR family of corepressors in the absence of hormone but releases from corep...

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Detalles Bibliográficos
Autores principales: Mengeling, Brenda J., Phan, Theresa Q., Goodson, Michael L., Privalsky, Martin L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039402/
https://ncbi.nlm.nih.gov/pubmed/21131350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200964
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