Aberrant Corepressor Interactions Implicated in PML-RARα and PLZF-RARα Leukemogenesis Reflect an Altered Recruitment and Release of Specific NCoR and SMRT Splice Variants

Human acute promyelocytic leukemia is causally linked to chromosomal translocations that generate chimeric retinoic acid receptor-α proteins (x-RARα fusions). Wild-type RARα is a transcription factor that binds to the SMRT/NCoR family of corepressors in the absence of hormone but releases from corep...

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Main Authors: Mengeling, Brenda J., Phan, Theresa Q., Goodson, Michael L., Privalsky, Martin L.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
主題:
Gene Regulation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039402/
https://ncbi.nlm.nih.gov/pubmed/21131350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200964
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