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Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines

BACKGROUND: STAT3 [1] has been shown to be dysregulated in nearly every major cancer, including osteosarcoma (OS). Constitutive activation of STAT3, via aberrant phosphorylation, leads to proliferation, cell survival and resistance to apoptosis. The present study sought to characterize the biologic...

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Detaylı Bibliyografya
Asıl Yazarlar: Couto, Jason I, Bear, Misty D, Lin, Jiayuh, Pennel, Michael, Kulp, Samuel K, Kisseberth, William C, London, Cheryl A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585923/
https://ncbi.nlm.nih.gov/pubmed/23244668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-8-244
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