Anti-Angiogenic Activity of a Small Molecule STAT3 Inhibitor LLL12

BACKGROUND: Recent data indicate the Signal Transducer and Activator of Transcription 3 (STAT3) pathway is required for VEGF production and angiogenesis in various types of cancers. STAT3 inhibitors have been shown to reduce tumor microvessel density in tumors but a direct anti-angiogenic activity h...

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Bibliografiske detaljer
Main Authors: Bid, Hemant K., Oswald, Duane, Li, Chenglong, London, Cheryl A., Lin, Jiayuh, Houghton, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328460/
https://ncbi.nlm.nih.gov/pubmed/22530037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035513
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