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Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines

BACKGROUND: STAT3 [1] has been shown to be dysregulated in nearly every major cancer, including osteosarcoma (OS). Constitutive activation of STAT3, via aberrant phosphorylation, leads to proliferation, cell survival and resistance to apoptosis. The present study sought to characterize the biologic...

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Detalhes bibliográficos
Main Authors: Couto, Jason I, Bear, Misty D, Lin, Jiayuh, Pennel, Michael, Kulp, Samuel K, Kisseberth, William C, London, Cheryl A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585923/
https://ncbi.nlm.nih.gov/pubmed/23244668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-8-244
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