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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
The tumor suppressor protein p53 serves as a critical regulator of a G1 cell cycle checkpoint and of apoptosis following exposure of cells to DNA-damaging agents. The mechanism by which DNA-damaging agents elevate p53 protein levels to trigger G1/S arrest or cell death remains to be elucidated. In f...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
1994
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358539/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8114714/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.3.1815 |
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