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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

The tumor suppressor protein p53 serves as a critical regulator of a G1 cell cycle checkpoint and of apoptosis following exposure of cells to DNA-damaging agents. The mechanism by which DNA-damaging agents elevate p53 protein levels to trigger G1/S arrest or cell death remains to be elucidated. In f...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Nelson, W G, Kastan, M B
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 1994
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358539/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8114714/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.3.1815
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