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Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta
DNA polymerase eta (pol η) is the only DNA polymerase causally linked to carcinogenesis in humans. Inherited deficiency of pol η in the variant form of xeroderma pigmentosum (XPV) predisposes to UV-light-induced skin cancer. Pol η-deficient cells demonstrate increased sensitivity to cisplatin and ox...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3584963/ https://ncbi.nlm.nih.gov/pubmed/22822095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs239 |
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