Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta

DNA polymerase eta (pol η) is the only DNA polymerase causally linked to carcinogenesis in humans. Inherited deficiency of pol η in the variant form of xeroderma pigmentosum (XPV) predisposes to UV-light-induced skin cancer. Pol η-deficient cells demonstrate increased sensitivity to cisplatin and ox...

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Hlavní autoři: Nicolay, Nils H., Carter, Rebecca, Hatch, Stephanie B., Schultz, Niklas, Prevo, Remko, McKenna, W. Gillies, Helleday, Thomas, Sharma, Ricky A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
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Original Manuscript
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584963/
https://ncbi.nlm.nih.gov/pubmed/22822095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs239
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