Overexpression of POLQ Confers a Poor Prognosis in Early Breast Cancer Patients

Depletion of POLQ (DNA polymerase theta) has recently been shown to render tumour cells more sensitive to radiotherapy whilst having little or no effect on normal tissues. This finding led us to investigate whether tumours that overexpress POLQ are associated with an adverse outcome. We therefore co...

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Autores principales: Higgins, Geoff S, Harris, Adrian L, Prevo, Remko, Helleday, Thomas, McKenna, W Gillies, Buffa, Francesca M
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2010
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917771/
https://ncbi.nlm.nih.gov/pubmed/20700469
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