Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta

DNA polymerase eta (pol η) is the only DNA polymerase causally linked to carcinogenesis in humans. Inherited deficiency of pol η in the variant form of xeroderma pigmentosum (XPV) predisposes to UV-light-induced skin cancer. Pol η-deficient cells demonstrate increased sensitivity to cisplatin and ox...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Nicolay, Nils H., Carter, Rebecca, Hatch, Stephanie B., Schultz, Niklas, Prevo, Remko, McKenna, W. Gillies, Helleday, Thomas, Sharma, Ricky A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
Original Manuscript
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584963/
https://ncbi.nlm.nih.gov/pubmed/22822095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs239
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires