Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

Metastasis is the main cause of death for cancer patients. Targeting factors that control metastasis formation is a major challenge for clinicians. Lysophosphatidic acid (LPA) is a bioactive phospholipid involved in cancer. LPA activates at least six independent G protein-coupled receptors (LPA(1–6)...

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Hlavní autoři: DAVID, MARION, RIBEIRO, JOHNNY, DESCOTES, FRANÇOISE, SERRE, CLAIRE-MARIE, BARBIER, MARYSE, MURONE, MAXIMILIEN, CLÉZARDIN, PHILIPPE, PEYRUCHAUD, OLIVIER
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584523/
https://ncbi.nlm.nih.gov/pubmed/22200658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1309
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