Cancer Cell Expression of Autotaxin Controls Bone Metastasis Formation in Mouse through Lysophosphatidic Acid-Dependent Activation of Osteoclasts

BACKGROUND: Bone metastases are highly frequent complications of breast cancers. Current bone metastasis treatments using powerful anti-resorbtive agents are only palliative indicating that factors independent of bone resorption control bone metastasis progression. Autotaxin (ATX/NPP2) is a secreted...

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Detalhes bibliográficos
Main Authors: David, Marion, Wannecq, Estelle, Descotes, Françoise, Jansen, Silvia, Deux, Blandine, Ribeiro, Johnny, Serre, Claire-Marie, Grès, Sandra, Bendriss-Vermare, Nathalie, Bollen, Mathieu, Saez, Simone, Aoki, Junken, Saulnier-Blache, Jean-Sébastien, Clézardin, Philippe, Peyruchaud, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840030/
https://ncbi.nlm.nih.gov/pubmed/20305819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009741
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