Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.

The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inactivating it. Consistent with a tumor suppressor fu...

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Bibliographic Details
Main Authors: Johnson, M R, DeClue, J E, Felzmann, S, Vass, W C, Xu, G, White, R, Lowy, D R
Format: Artigo
Language:Inglês
Published: 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC358413/
https://ncbi.nlm.nih.gov/pubmed/8264632
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