Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.

The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inactivating it. Consistent with a tumor suppressor fu...

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Publicat a:Mol Cell Biol
Autors principals: Johnson, M R, DeClue, J E, Felzmann, S, Vass, W C, Xu, G, White, R, Lowy, D R
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358413/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8264632/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.1.641
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