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Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.
The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inactivating it. Consistent with a tumor suppressor fu...
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| 出版年: | Mol Cell Biol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
1994
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358413/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8264632/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.1.641 |
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