A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1.

A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (S39C), and Arg-41 changed to Leu. Of these, the co...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: DeClue, J E, Stone, J C, Blanchard, R A, Papageorge, A G, Martin, P, Zhang, K, Lowy, D R
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360160/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2038322/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.6.3132
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