A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1.

A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (S39C), and Arg-41 changed to Leu. Of these, the co...

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Detaylı Bibliyografya
Asıl Yazarlar: DeClue, J E, Stone, J C, Blanchard, R A, Papageorge, A G, Martin, P, Zhang, K, Lowy, D R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1991
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC360160/
https://ncbi.nlm.nih.gov/pubmed/2038322
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