A ras effector domain mutant which is temperature sensitive for cellular transformation: interactions with GTPase-activating protein and NF-1.

A series of v-rasH effector domain mutants were analyzed for their ability to transform rat 2 cells at either low or high temperatures. Three mutants were found to be significantly temperature sensitive: Ile-36 changed to Leu, Ser-39 changed to Cys (S39C), and Arg-41 changed to Leu. Of these, the co...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	DeClue, J E, Stone, J C, Blanchard, R A, Papageorge, A G, Martin, P, Zhang, K, Lowy, D R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360160/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2038322/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.6.3132-3138.1991
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