A Cell-Delivered and –Activated SN38-Dextran Prodrug Increases Survival in a Murine Disseminated Pancreatic Cancer Model

Enzyme activated prodrugs have been investigated and sought after as highly specific, low side effect treatments, especially for cancer therapy. Unfortunately, excellent targets for enzyme activated therapy are rare. Here we demonstrate a system based on cell delivery that can carry both a prodrug a...

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Autors principals: Basel, Matthew T., Balivada, Sivasai, Shrestha, Tej B., Seo, Gwi-Moon, Pyle, Marla M., Tamura, Masaaki, Bossmann, Stefan H., Troyer, Deryl L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583224/
https://ncbi.nlm.nih.gov/pubmed/22238072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201101879
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