Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

The targeted delivery of therapeutics to the tumor site is highly desirable in cancer treatment, because it is capable of minimizing collateral damage. Herein, we report the synthesis of a nanoplatform, which is composed of a 15 ± 1 nm diameter core/shell Fe/Fe3O4 magnetic nanoparticles (MNPs) and t...

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Hauptverfasser: Hongwang Wang, Tej B. Shrestha, Matthew T. Basel, Raj K. Dani, Gwi-Moon Seo, Sivasai Balivada, Marla M. Pyle, Heidy Prock, Olga B. Koper, Prem S. Thapa, David Moore, Ping Li, Viktor Chikan, Deryl L. Troyer, Stefan H. Bossmann
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2012-06-01
Schriftenreihe:Beilstein Journal of Nanotechnology
Schlagworte:
cell-based delivery
chemotherapeutic prodrug
magnetic Fe/Fe3O4 nanoparticles
SN38
Online Zugang:https://doi.org/10.3762/bjnano.3.51
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