Magnetic-Fe/Fe(3)O(4)-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

The targeted delivery of therapeutics to the tumor site is highly desirable in cancer treatment, because it is capable of minimizing collateral damage. Herein, we report the synthesis of a nanoplatform, which is composed of a 15 ± 1 nm diameter core/shell Fe/Fe(3)O(4) magnetic nanoparticles (MNPs) a...

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Autors principals: Wang, Hongwang, Shrestha, Tej B, Basel, Matthew T, Dani, Raj Kumar, Seo, Gwi-Moon, Balivada, Sivasai, Pyle, Marla M, Prock, Heidy, Koper, Olga B, Thapa, Prem S, Moore, David, Li, Ping, Chikan, Viktor, Troyer, Deryl L, Bossmann, Stefan H
Format: Artigo
Idioma:Inglês
Publicat: Beilstein-Institut 2012
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Full Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388369/
https://ncbi.nlm.nih.gov/pubmed/23016149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjnano.3.51
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