A self-contained enzyme activating prodrug cytotherapy for preclinical melanoma

Gene-directed enzyme prodrug therapy (GDEPT) has been investigated as a means of cancer treatment without affecting normal tissues. This system is based on the delivery of a suicide gene, a gene encoding an enzyme which is able to convert its substrate from non-toxic prodrug to cytotoxin. In this ex...

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Bibliografiska uppgifter
Huvudupphovsmän: Seo, Gwi-Moon, Rachakatla, Raja Shekar, Balivada, Sivasai, Pyle, Marla, Shrestha, Tej B., Basel, Matthew T., Myers, Carl, Wang, Hongwang, Tamura, Masaaki, Bossmann, Stefan H., Troyer, Deryl L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222711/
https://ncbi.nlm.nih.gov/pubmed/21567204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11033-011-0720-7
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