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Endoglin Deficiency in Bone Marrow Is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse after VEGF Stimulation

BACKGROUND AND PURPOSE: Bone marrow-derived cells (BMDCs) home to vascular endothelial growth factor (VEGF)-induced brain angiogenic foci, and VEGF induces cerebrovascular dysplasia in adult endoglin heterozygous (Eng(+/−)) mice. We hypothesized that Eng(+/−) BMDCs cause cerebrovascular dysplasia in...

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Detalhes bibliográficos
Main Authors: Choi, Eun-Jung, Walker, Espen J., Degos, Vincent, Jun, Kristine, Kuo, Robert, Pile-Spellman, John, Su, Hua, Young, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582755/
https://ncbi.nlm.nih.gov/pubmed/23306322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.112.671974
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