Negative feedback by IRE1β optimizes mucin production in goblet cells

In mammals, the prototypical endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1 (IRE1) has diverged into two paralogs. IRE1α is broadly expressed and mediates the unconventional splicing of X-box binding protein 1 (XBP1) mRNA during ER stress. By contrast, IRE1β is expressed select...

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Bibliografiske detaljer
Main Authors: Tsuru, Akio, Fujimoto, Naoko, Takahashi, Satsuki, Saito, Michiko, Nakamura, Daisuke, Iwano, Megumi, Iwawaki, Takao, Kadokura, Hiroshi, Ron, David, Kohno, Kenji
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581977/
https://ncbi.nlm.nih.gov/pubmed/23386727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212484110
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