Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac Disease Mechanism

Titin plays crucial roles in sarcomere organization and cardiac elasticity by acting as an intrasarcomeric molecular spring. A mutation in the tenth Ig-like domain of titin's spring region is associated with arrhythmogenic cardiomyopathy, a disease characterized by ventricular arrhythmias leadi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Anderson, Brian R., Bogomolovas, Julius, Labeit, Siegfried, Granzier, Henk
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581406/
https://ncbi.nlm.nih.gov/pubmed/23297410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401372
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker