Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability as a Cardiac Disease Mechanism

Titin plays crucial roles in sarcomere organization and cardiac elasticity by acting as an intrasarcomeric molecular spring. A mutation in the tenth Ig-like domain of titin's spring region is associated with arrhythmogenic cardiomyopathy, a disease characterized by ventricular arrhythmias leadi...

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Detaylı Bibliyografya
Asıl Yazarlar: Anderson, Brian R., Bogomolovas, Julius, Labeit, Siegfried, Granzier, Henk
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Molecular Biophysics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581406/
https://ncbi.nlm.nih.gov/pubmed/23297410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401372
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