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Removal of immunoglobulin-like domains from titin’s spring segment alters titin splicing in mouse skeletal muscle and causes myopathy

Titin is a molecular spring that determines the passive stiffness of muscle cells. Changes in titin’s stiffness occur in various myopathies, but whether these are a cause or an effect of the disease is unknown. We studied a novel mouse model in which titin’s stiffness was slightly increased by delet...

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Detalhes bibliográficos
Main Authors: Buck, Danielle, Smith, John E., Chung, Charles S., Ono, Yasuko, Sorimachi, Hiroyuki, Labeit, Siegfried, Granzier, Henk L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001778/
https://ncbi.nlm.nih.gov/pubmed/24470489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311129
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