AAV-Mediated Gene Therapy in the Guanylate Cyclase (RetGC1/RetGC2) Double Knockout Mouse Model of Leber Congenital Amaurosis

Mutations in GUCY2D are associated with recessive Leber congenital amaurosis-1 (LCA1). GUCY2D encodes photoreceptor-specific, retinal guanylate cyclase-1 (RetGC1). Reports of retinal degeneration in LCA1 are conflicting; some describe no obvious degeneration and others report loss of both rods and c...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Boye, Sanford L., Peshenko, Igor V., Huang, Wei Chieh, Min, Seok Hong, McDoom, Issam, Kay, Christine N., Liu, Xuan, Dyka, Frank M., Foster, Thomas C., Umino, Yumiko, Karan, Sukanya, Jacobson, Samuel G., Baehr, Wolfgang, Dizhoor, Alexander, Hauswirth, William W., Boye, Shannon E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Mary Ann Liebert, Inc. 2013
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581260/
https://ncbi.nlm.nih.gov/pubmed/23210611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.193
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