Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets

The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility whe...

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Detalhes bibliográficos
Main Authors: Travers, Mary E., Mackay, Deborah J.G., Dekker Nitert, Marloes, Morris, Andrew P., Lindgren, Cecilia M., Berry, Andrew, Johnson, Paul R., Hanley, Neil, Groop, Leif C., McCarthy, Mark I., Gloyn, Anna L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Genetics/Genomes/Proteomics/Metabolomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581222/
https://ncbi.nlm.nih.gov/pubmed/23139357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0819
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