Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets

The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility whe...

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Autori principali: Travers, Mary E., Mackay, Deborah J.G., Dekker Nitert, Marloes, Morris, Andrew P., Lindgren, Cecilia M., Berry, Andrew, Johnson, Paul R., Hanley, Neil, Groop, Leif C., McCarthy, Mark I., Gloyn, Anna L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2013
Soggetti:
Genetics/Genomes/Proteomics/Metabolomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581222/
https://ncbi.nlm.nih.gov/pubmed/23139357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0819
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