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Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC Antagonist

A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanometh...

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Main Authors: Chen, Haijun, Ding, Chunyong, Wild, Christopher, Liu, Huiling, Wang, Tianzhi, White, Mark A., Cheng, Xiaodong, Zhou, Jia
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580859/
https://ncbi.nlm.nih.gov/pubmed/23459418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2013.01.024
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