Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

The cAMP signaling cascade is one of the most frequently targeted pathways for the development of pharmaceutics. A plethora of recent genetic and pharmacological studies suggest that exchange proteins directly activated by cAMP (EPACs) are implicated in multiple pathologies. Selective EPAC inhibitor...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhu, Yingmin, Chen, Haijun, Boulton, Stephen, Mei, Fang, Ye, Na, Melacini, Giuseppe, Zhou, Jia, Cheng, Xiaodong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366844/
https://ncbi.nlm.nih.gov/pubmed/25791905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09344
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