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Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists
EPAC1 and EPAC2, two isoforms of exchange proteins directly activated by cAMP (EPAC), respond to the second messenger cAMP and regulate a wide variety of intracellular processes under physiological and pathophysiological circumstances. Herein, we report the chemical design, synthesis, and pharmacolo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574212/ https://ncbi.nlm.nih.gov/pubmed/23286832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3014162 |
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