Exchange Protein Directly Activated by Cyclic AMP Isoform 2 Is Not a Direct Target of Sulfonylurea Drugs

por Tsalkova, Tamara, Gribenko, Alexey V., Cheng, Xiaodong
Publicado 2011

A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

por Tsalkova, Tamara, Mei, Fang C., Cheng, Xiaodong
Publicado 2012

Epac and PKA: a tale of two intracellular cAMP receptors

por Cheng, Xiaodong, Ji, Zhenyu, Tsalkova, Tamara, Mei, Fang
Publicado 2008

Conformational States of Exchange Protein Directly Activated by cAMP (EPAC1) Revealed by Ensemble Modeling and Integrative Structural Biology

por White, Mark Andrew, Tsalkova, Tamara, Mei, Fang C., Cheng, Xiaodong
Publicado en Cells (2019)

Effect of Glutathione on Homo- and Heterotropic Cooperativity in Cytochrome P450 3A4

por Davydov, Dmitri R., Davydova, Nadezhda Y., Tsalkova, Tamara N., Halpert, James R.
Publicado 2008

Mechanism of interactions of α-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe

por Tsalkova, Tamara N., Davydova, Nadezhda Y., Halpert, James R., Davydov, Dmitri R.
Publicado 2007

Mechanism of Epac Activation: STRUCTURAL AND FUNCTIONAL ANALYSES OF Epac2 HINGE MUTANTS WITH CONSTITUTIVE AND REDUCED ACTIVITIES

por Tsalkova, Tamara, Blumenthal, Donald K., Mei, Fang C., White, Mark A., Cheng, Xiaodong
Publicado 2009

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as Potent Antagonists Targeting Exchange Proteins Directly Activated by cAMP

por Chen, Haijun, Tsalkova, Tamara, Mei, Fang C., Hu, Yaohua, Cheng, Xiaodong, Zhou, Jia
Publicado 2012

Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP

por White, Mark A., Li, Sheng, Tsalkova, Tamara, Mei, Fang C., Liu, Tong, Woods, Virgil L., Cheng, Xiaodong
Publicado 2012

Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

por Chen, Haijun, Tsalkova, Tamara, Chepurny, Oleg G., Mei, Fang C., Holz, George G., Cheng, Xiaodong, Zhou, Jia
Publicado 2013

A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion

por Almahariq, Muayad, Tsalkova, Tamara, Mei, Fang C., Chen, Haijun, Zhou, Jia, Sastry, Sarita K., Schwede, Frank, Cheng, Xiaodong
Publicado 2013

Mechanism of Intracellular cAMP Sensor Epac2 Activation: cAMP-INDUCED CONFORMATIONAL CHANGES IDENTIFIED BY AMIDE HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY (DXMS)

por Li, Sheng, Tsalkova, Tamara, White, Mark A., Mei, Fang C., Liu, Tong, Wang, Daphne, Woods, Virgil L., Cheng, Xiaodong
Publicado 2011

Isoform-specific antagonists of exchange proteins directly activated by cAMP

por Tsalkova, Tamara, Mei, Fang C., Li, Sheng, Chepurny, Oleg G., Leech, Colin A., Liu, Tong, Holz, George G., Woods, Virgil L., Cheng, Xiaodong
Publicado 2012

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

por Chepurny, Oleg G., Bertinetti, Daniela, Diskar, Mandy, Leech, Colin A., Afshari, Parisa, Tsalkova, Tamara, Cheng, Xiaodong, Schwede, Frank, Genieser, Hans-G., Herberg, Friedrich W., Holz, George G.
Publicado 2013