Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP

Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we have combined site-directed mutagenesis, X-ray crystallography, and peptide amide hydrogen/deuterium ex...

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Detalhes bibliográficos
Main Authors: White, Mark A., Li, Sheng, Tsalkova, Tamara, Mei, Fang C., Liu, Tong, Woods, Virgil L., Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506601/
https://ncbi.nlm.nih.gov/pubmed/23189173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049932
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