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The action of selective CRAC channel blockers is affected by the Orai pore geometry

As the molecular composition of calcium-release activated calcium (CRAC) channels has been unknown for two decades, elucidation of selective inhibitors has been considerably hampered. By the identification of the two key components of CRAC channels, STIM1 and Orai1 have emerged as promising targets...

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Detalhes bibliográficos
Main Authors: Derler, Isabella, Schindl, Rainer, Fritsch, Reinhard, Heftberger, Peter, Riedl, Maria Christine, Begg, Malcolm, House, David, Romanin, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580291/
https://ncbi.nlm.nih.gov/pubmed/23218667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2012.11.005
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