Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis

The aspartic protease cathepsin-D (cath-D) is a marker of poor prognosis in breast cancer that is overexpressed and hypersecreted by human breast cancer cells. Secreted pro-cath-D binds to the extracellular domain of the β chain of the LDL receptor-related protein-1 (LRP1) in fibroblasts. The LRP1 r...

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Bibliografiska uppgifter
Huvudupphovsmän: Derocq, Danielle, Prébois, Christine, Beaujouin, Mélanie, Laurent-Matha, Valérie, Pattingre, Sophie, Smith, Gary K., Liaudet-Coopman, Emmanuelle
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579766/
https://ncbi.nlm.nih.gov/pubmed/22081071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.501
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