Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

Interactions between cancer cells and fibroblasts are crucial in cancer progression. We have previously shown that the aspartic protease cathepsin-D (cath-D), a marker of poor prognosis in breast cancer that is overexpressed and highly secreted by breast cancer cells, triggers mouse embryonic fibrob...

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Main Authors: Beaujouin, Mélanie, Prébois, Christine, Derocq, Danielle, Laurent-Matha, Valérie, Masson, Olivier, Pattingre, Sophie, Coopman, Peter, Bettache, Nadir, Grossfield, Jami, Hollingsworth, Robert E., Zhang, Hongyu, Yao, Zemin, Hyman, Bradley T., Van Der Geer, Peter, Smith, Gary K., Liaudet-Coopman, Emmanuelle
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964349/
https://ncbi.nlm.nih.gov/pubmed/20826454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.070938
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