Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis

Eitemau Tebyg

• Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth
  gan: Beaujouin, Mélanie, et al.
  Cyhoeddwyd: (2010)
• Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
  gan: Laurent-Matha, Valérie, et al.
  Cyhoeddwyd: (2006)
• Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity
  gan: Beaujouin, Mélanie, et al.
  Cyhoeddwyd: (2008)
• Catalytically inactive human cathepsin D triggers fibroblast invasive growth
  gan: Laurent-Matha, Valérie, et al.
  Cyhoeddwyd: (2005)
• Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells
  gan: Bach, Anne-Sophie, et al.
  Cyhoeddwyd: (2015)