Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities

BACKGROUND AND PURPOSE: Drugs targeting microtubules are commonly used for cancer treatment. However, the potency of microtubule inhibitors used clinically is limited by the emergence of resistance. We thus designed a strategy to find new cell-permeable microtubule-targeting agents. EXPERIMENTAL APP...

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Main Authors: Prudent, Renaud, Vassal-Stermann, Émilie, Nguyen, Chi-Hung, Mollaret, Marjorie, Viallet, Jean, Desroches-Castan, Agnès, Martinez, Anne, Barette, Caroline, Pillet, Catherine, Valdameri, Glaucio, Soleilhac, Emmanuelle, Di Pietro, Attilio, Feige, Jean-Jacques, Billaud, Marc, Florent, Jean-Claude, Lafanechère, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579287/
https://ncbi.nlm.nih.gov/pubmed/23004938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02230.x
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