A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras

The efficacy of anti-angiogenic therapies on cancer patients is limited by the emergence of drug resistance, urging the search for second-generation drugs. In this study, we screened an academic chemical library (DCM, University of Grenoble-Alpes) and identified a leader molecule, COB223, that inhib...

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Publicado en:Oncotarget
Autores principales: Desroches-Castan, Agnès, Quélard, Delphine, Demeunynck, Martine, Constant, Jean-François, Dong, Chongling, Keramidas, Michelle, Coll, Jean-Luc, Barette, Caroline, Lafanechère, Laurence, Feige, Jean-Jacques
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467156/
https://ncbi.nlm.nih.gov/pubmed/25742784
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