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Structure-Activity Relationships of Truncated Adenosine Derivatives as Highly Potent and Selective Human A(3) Adenosine Receptor Antagonists

On the basis of potent and selective binding affinity of truncated 4′-thioadenosine derivatives at the human A(3) adenosine receptor (AR), their bioisosteric 4′-oxo derivatives were designed and synthesized from commercially available 2,3-O-isopropylidene-d-erythrono lactone. The derivatives tested...

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Dettagli Bibliografici
Autori principali: Pal, Shantanu, Choi, Won Jun, Choe, Seung Ah, Heller, Cara L., Gao, Zhan-Guo, Chinn, Moshe, Jacobson, Kenneth A., Hou, Xiyan, Lee, Sang Kook, Kim, Hea Ok, Jeong, Lak Shin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578599/
https://ncbi.nlm.nih.gov/pubmed/19375920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.03.034
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