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A Reduced Zinc Diet or Zinc Transporter 3 Knockout Attenuate Light Induced Zinc Accumulation and Retinal Degeneration

Our previous study on retinal light exposure suggests the involvement of zinc (Zn(2+)) toxicity in the death of RPE and photoreceptors (LD) which could be attenuated by pyruvate and nicotinamide, perhaps through restoration of NAD(+) levels. In the present study, we examined Zn(2+) toxicity, and the...

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Detalhes bibliográficos
Main Authors: Bai, Shi, Sheline, Carolyn R., Zhou, Yongdong, Sheline, Christian T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578048/
https://ncbi.nlm.nih.gov/pubmed/23274584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2012.12.008
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