Liver-Specific, but Not Retina-Specific, Hepcidin Knockout Causes Retinal Iron Accumulation and Degeneration

The liver secretes hepcidin (Hepc) into the bloodstream to reduce blood iron levels. Hepc accomplishes this by triggering degradation of the only known cellular iron exporter ferroportin in the gut, macrophages, and liver. We previously demonstrated that systemic Hepc knockout (HepcKO) mice, which h...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Baumann, Bailey H., Shu, Wanting, Song, Ying, Sterling, Jacob, Kozmik, Zbynek, Lakhal-Littleton, Samira, Dunaief, Joshua L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6723216/
https://ncbi.nlm.nih.gov/pubmed/31287995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.05.022
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