Dietary Zinc Reduction, Pyruvate Supplementation, or Zinc Transporter 5 Knockout Attenuates β-Cell Death in Nonobese Diabetic Mice, Islets, and Insulinoma Cells(1)(2)(3)

Pancreatic zinc (Zn(2+)) concentrations are linked to diabetes and pancreatic dysfunction, but Zn(2+) is also required for insulin processing and packaging. Zn(2+) released with insulin increases β-cell pancreatic death after streptozotocin toxin exposure in vitro and in vivo. Triosephosphate accumu...

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Main Authors: Sheline, Christian T., Shi, Chunxiao, Takata, Toshihiro, Zhu, Julia, Zhang, Wenlan, Sheline, P. Joshua, Cai, Ai-Li, Li, Li
格式: Artigo
語言:Inglês
出版: American Society for Nutrition 2012
主題:
Nutrition and Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497962/
https://ncbi.nlm.nih.gov/pubmed/23096014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.112.167031
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