scAAV-Mediated Gene Transfer of Interleukin 1-Receptor Antagonist to Synovium and Articular Cartilage in Large Mammalian Joints

With the long-term goal of developing a gene-based treatment for osteoarthritis (OA), we performed studies to evaluate the equine joint as a model for AAV-mediated gene transfer to large, weight-bearing human joints. A self-complementary AAV2 vector containing the coding regions for human interleuki...

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Autori principali: Watson, Rachael S., Broome, Ted A., Levings, Padraic P., Rice, Bret L., Kay, Jesse D., Smith, Andrew D., Gouze, Elvire, Gouze, Jean-Noel, Dacanay, E. Anthony, Hauswirth, William W., Nickerson, David M., Dark, Michael J., Colahan, Patrick T., Ghivizzani, Steven C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577988/
https://ncbi.nlm.nih.gov/pubmed/23151520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2012.81
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