Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahyroquinoline Library

[Image: see text] A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques. A tetrahydroquinoline (THQ) scaffold was prepared via an asymmetric Povarov reaction using cooperative catalysis to generate thre...

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Detalhes bibliográficos
Main Authors: Gerard, Baudouin, O’Shea, Morgan Welzel, Donckele, Etienne, Kesavan, Sarathy, Akella, Lakshmi B., Xu, Hao, Jacobsen, Eric N., Marcaurelle, Lisa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577964/
https://ncbi.nlm.nih.gov/pubmed/23088641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co300098v
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