Distinct Roles of Molecular Chaperones HSP90α and HSP90β in the Biogenesis of KCNQ4 Channels

Loss-of-function mutations in the KCNQ4 channel cause DFNA2, a subtype of autosomal dominant non-syndromic deafness that is characterized by progressive sensorineural hearing loss. Previous studies have demonstrated that the majority of the pathogenic KCNQ4 mutations lead to trafficking deficiency a...

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Bibliografiske detaljer
Main Authors: Gao, Yanhong, Yechikov, Sergey, Vazquez, Ana E., Chen, Dongyang, Nie, Liping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576372/
https://ncbi.nlm.nih.gov/pubmed/23431407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057282
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