Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss

KCNQ4, a voltage-gated potassium channel, plays an important role in maintaining cochlear ion homoeostasis and regulating hair cell membrane potential, both essential for normal auditory function. Mutations in the KCNQ4 gene lead to DFNA2, a subtype of autosomal dominant non-syndromic deafness that...

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Библиографические подробности
Главные авторы: Gao, Yanhong, Yechikov, Sergey, Vázquez, Ana E, Chen, Dongyang, Nie, Liping
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729637/
https://ncbi.nlm.nih.gov/pubmed/23750663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12080
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