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Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss
KCNQ4, a voltage-gated potassium channel, plays an important role in maintaining cochlear ion homoeostasis and regulating hair cell membrane potential, both essential for normal auditory function. Mutations in the KCNQ4 gene lead to DFNA2, a subtype of autosomal dominant non-syndromic deafness that...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729637/ https://ncbi.nlm.nih.gov/pubmed/23750663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12080 |
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