Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss

KCNQ4, a voltage-gated potassium channel, plays an important role in maintaining cochlear ion homoeostasis and regulating hair cell membrane potential, both essential for normal auditory function. Mutations in the KCNQ4 gene lead to DFNA2, a subtype of autosomal dominant non-syndromic deafness that...

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Autores principales: Gao, Yanhong, Yechikov, Sergey, Vázquez, Ana E, Chen, Dongyang, Nie, Liping
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729637/
https://ncbi.nlm.nih.gov/pubmed/23750663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12080
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